Table 6.
Chemical structure of oxadiazole-amides and 2-aminobenzothiazoles.
| ||||||
|---|---|---|---|---|---|---|
| COMPOUND | SCAFFOLD NUMBER | R1 | R2 | R3 | X | IC50 (μM) |
| 673 | 1 | n-butyl | 32.87 ± 0.04 | |||
| 674 | 1 | Ph-trio-Ethyl | 13.81 ± 0.03 | |||
| 675 | 1 | Ph-CH=CH | 3.79 ± 0.02 | |||
| 676 | 2 | 2,4-diMe | O | 10.35 ± 0.12 | ||
| 677 | 2 | 2,5-diMe | S | 13.09 ± 0.06 | ||
| 678 | 3 | 2,4-diMe-Ph | 2-Cl | 36.04 ± 0.03 | ||
| 679 | 3 | 2-Cl-Ph | 3-O-Ph | 3.43 ± 0.04 | ||
| 680 | 4 | 4-Br-Ph | t-but | 28.36 ± 0.07 | ||
| 681 | 4 | 2-furanyl | 4-EtS-Ph | 20.73 ± 0.03 | ||
| 682 | 4 | 2,4-diMe-Ph | Ph-O-Ethyl | 15.14 ± 0.06 | ||
| 683 | 5 |
|
|
4-Ethyl | 10.43 ± 0.04 | |
| 684 | 5 |
|
5,7-dimethyl | 29.93 ± 0.05 | ||
| 685 | 5 |
|
|
4,6-difluoro | 20.42 ± 0.06 | |
| 686 | 5 |
|
H | 6-Acetylamino | 1.94 ± 0.06 | |