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. Author manuscript; available in PMC: 2016 Apr 13.
Published in final edited form as: Eur J Med Chem. 2014 Sep 16;94:480–488. doi: 10.1016/j.ejmech.2014.09.047

Figure 2.

Figure 2

Alanine scanning mutagenesis of interfacial residues reveals the importance of each residue to complex formation. The example depicts mutation of a key tryptophan from the p53 (yellow ribbon) activation helix in complex with Mdm2 (blue).