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Helical interfaces can be divided between those that feature clefts for binding and those with extended interfaces. The cleft interfaces feature a high density of important contacts in a small region. The p53/MDM2 (left: p53 in green, MDM2 in grey; PDB code: 1YCR) and cyclin-dependent kinase6/D-type viral cyclin (right: cdk6 in green, D-type viral cyclin in grey; PDB code: 1G3N) complexes are representative examples of binding cleft and extended interfaces, respectively.
