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Ras/Sos and Ras/Raf are implicated in the MAP/ERK signaling pathway. Ras interacts with Sos only when a receptor tyrosine kinase binds its substrate and recruits Sos to the membrane. Following the Ras/Raf association depicted, Raf phosphorylates Mek, which phosphorylates MAPK, which modulates the activity of many downstream effectors.
