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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Dev Neurobiol. 2014 Sep 13;75(10):1068–1079. doi: 10.1002/dneu.22230

Figure 1. Behavioral effects of SC560 and NS398.

Figure 1

All pups were injected with formalin since saline injections to the paw do not produce nociceptive responses. The nociceptive response is on the Y-axis. The gray shaded area is the 95% confidence interval for the vehicle + formalin treated pups. The confidence interval shows both the effect size and significance (points outside the 95% confidence interval are significant p<.05) for individual bins. There was no drug effect or drug X bin interaction at 3 or 10 days of age for either drug, although there was a trend for SC560 to increase responding at 10 days of age. In contrast, at 21 days of age both drugs were equally effective at reducing the nociceptive response. The effect is consistent at all phases of the response. N=8, 9, and 8 for PN3, PN10 and PN21 for SC560; N=8, 12, and 8 for PN3, PN10 and PN21 for NS398.