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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Biol Psychiatry. 2014 Sep 16;78(9):635–646. doi: 10.1016/j.biopsych.2014.09.002

Table 2. Summary of significant clusters from the between-group emotion-dependent functional connectivity analysis of mPFC.

Regions are the result of a psychophysiological interaction (PPI) method of functional connectivity and corrected for multiple comparisons at a cluster-wise threshold of p<0.05. Locations are reported according to the center of mass of cluster in MNI coordinates (radiological convention). Functional connectivity values are reported as mean ± SEM. Resting-state (RS) functional connectivity values were extracted from the regions exhibiting significant between-group differences on the PPI analysis (see Methods for more details). See also Figure 3.

Region (Brodmann's Area) Location (x,y,z) # of voxels Statistic(F1,61) MDD (PPI) HCL (PPI) MDD(RS) HCL (RS)
Directionality: MDD > HCL
Precuneus (BA 7) 8, -67, 38 321 6.39 0.068 ± 0.01 0.018 ± 0.008 0.255 ± 0.03 0.268 ± 0.03
Cingulate gyrus (BA23/24) -6, -1, 30 176 6.30 0.073 ± 0.01 0.021 ± 0.007 0.087 ± 0.02 0.083 ± 0.02
L inferior parietal lobule, supramarginal gyrus -50, -52, 34 72 5.43 0.071 ± 0.01 0.022 ± 0.008 0.310 ± 0.03 0.242 ± 0.03