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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Biol Psychiatry. 2014 Sep 16;78(9):635–646. doi: 10.1016/j.biopsych.2014.09.002

Table 3. Summary of significant clusters from the between-group emotion-dependent functional connectivity analysis of PCC.

Regions are the result of a psychophysiological (PPI) method of functional connectivity and corrected for multiple comparisons at a cluster-wise threshold of p<0.05. Locations are reported according to the center of mass of cluster in MNI coordinates (radiological convention). Functional connectivity values are reported as mean ± SEM. Resting-state (RS) functional connectivity values were extracted from the regions exhibiting significant between-group differences on the PPI analysis (see Methods for more details). See also Figure 4.

Region(Brodmann's Area) Location (x,y,z) # of voxels Statistic(F1,61) MDD (PPI) HCL (PPI) MDD (RS) HCL (RS)
Directionality: MDD > HCL
Precuneus (BA 7) 5, -65, 37 195 6.25 0.078 ± 0.02 0.023± 0.009 0.481 ± 0.03 0.454 ± 0.02
R cingulate gyrus (BA 31/23) 14, -26, 32 179 5.42 0.081 ± 0.01 0.030± 0.008 0.205 ± 0.02 0.200 ± 0.01
L dorsal striatum, subcallosal cingulate gyrus -17, 17, -4 63 5.49 0.063 ± 0.01 0.008 ± 0.01 0.155 ± 0.03 0.193 ± 0.02