Figure 1.
Flowchart of the clinical trials with tobramycin in CF.
Abbreviations: CF, cystic fibrosis; TIS, tobramycin inhaled solution; FEV1, forced expiratory volume in 1 second; IV, intravenous; TIP, tobramycin inhaled powder; EVOLVE, Evaluate tobramycin inhaled dry powder efficacy trial; BID, twice a day; EAGER, Establish a new gold standard efficacy and safety with tobramycin in cystic fibrosis trial; EDIT, Establish tobramycin dry powder efficacy in cystic fibrosis trial; EPIC, Early Pseudomonas Infection Control trial; ELITE, EarLy Inhaled Tobramycin for Eradication trial.