Table 2.
Inflammatory Biomarkers in Serum and Tissue.
| Inflammatory biomarker | Control n = 16 M (SD) |
Control + drug n = 16 M (SD) |
Tumor n = 16 M (SD) |
Tumor + drug n = 16 M (SD) |
Test statistic |
|---|---|---|---|---|---|
| Cytokines | |||||
| Serum (pg/ml) | |||||
| IL-6 | 9.4 (9.4) | 7.9 (7.7) | 241.1 (162.8) | 240.5 (166.2) | F(1, 64) = 62.8***,a |
| TNFR1 | 690.3 (251.2) | 813.4 (204.2) | 1284.1 (595.6) | 1341.1 (405.6) | F(1, 64) = 33.8***,a |
| Heart (ddct) | |||||
| IL-6 | .95 (.69) | .50 (.35) | 5.7 (2.9) | 7.0 (5.8) | F(1, 64) = 43.6***,a |
| TNFR1 | 1.0 (.19) | .95 (2.0) | 2.2 (.60) | 3.4 (2.6) | F(1, 64) = 27.1***,a |
| Gastrocnemius (ddct) | |||||
| IL-6 | 1.1 (1.0) | .51 (.23) | 1.3 (1.0) | 1.8 (2.3) | F(1, 64) = 4.2*,a |
| TNFR1 | 1.1 (.47) | .94 (.43) | 1.7 (.72) | 1.7 (.64) | F(1, 64) = 22.4***,a |
| GSH/GSSG (μM) | |||||
| Heart | 6.8 (3.5) | 5.9 (2.1) | 3.2 (.6) | 3.3 (.78) | F(1, 60) = 34.5***,a |
| Gastrocnemius | 5.2 (1.2) | 4.9 (1.3) | 4.1 (1.3) | 4.9 (1.3) | ns |
Note. ddct = relative to expression of GAPDH; GADPH = glyceraldehyde-3-phosphate dehydrogenase; IL = interleukin; GSH/GSSG = ratio of reduced sulfhydryl glutathione to oxidized glutathione; TNFR1 = tumor necrosis factor-α type 1 receptor.
a
Main effect of tumor.
*
p < .05.
**
p < .01.
***
p < .001.