Skip to main content
. Author manuscript; available in PMC: 2015 Oct 23.
Published in final edited form as: Mol Cell. 2014 Sep 25;56(2):298–310. doi: 10.1016/j.molcel.2014.08.022

Figure 6. Binding H3K36me3 is important for BS69 to regulate alternative splicing.

Figure 6

(A) and (B) Knockdown of SETD2 by two independent shRNAs in HeLa cells caused a decrease in IR (A) and an altered ratio of ES (B) of BS69 target genes. (C) and (D) Wild type but not the PWWP FW point mutant rescued the alteration of IR (C) and ES (D) caused by BS69 knockdown. Data are represented mean ± SEM from 3 biological replicates, *P<0.05, **P<0.01; n.s., not significant. See also Figure S6.