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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Fertil Steril. 2015 Jan 14;103(3):845–852. doi: 10.1016/j.fertnstert.2014.12.099

Figure 4. BMP-2 stimulated HOXA10 and LIF expression in LCM treated ESC: Effect of transfection with mutant TGF-β receptor.

Figure 4

Figure 4

BMP-2 stimulated expression of HOXA10 and LIF was examined in LCM exposed ESC that had been transfected with mutant TGF-β Type II receptor or vector control. A: BMP-2 stimulated HOXA10 expression. BMP-2 stimulated HOXA10 expression was repressed in LCM exposed ESC that had been transfected with vector control plasmid, compared to non LCM exposed controls (0.33 fold, p<0.05). BMP-2 stimulated HOXA10 expression was not significantly changed, compared to non LCM exposed control ESC, when ESC had been transfected with mutant TGF-β Type II receptor prior to LCM exposure. B: BMP-2 stimulated LIF expression. BMP-2 stimulated LIF expression was repressed LCM exposed ESC that had been transfected with vector control plasmid, compared to non LCM exposed control ESC (0.64 fold, p<0.05). BMP-2 stimulated LIF expression was significantly increased, compared to non LCM exposed control ESC, when ESC had been transfected with mutant TGF-β Type II receptor prior to LCM exposure (1.57 fold, p<0.05).

* denotes statistical significance with p<0.05