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Overnight fasting Wistar Han rats (5 per group) were administered (iv) 2.5 mg/kg bodyweight of analogue 4 or analogue 8, 10 min postglucose challenge. Glibenclamide was administered orally at −30 min. (A) The effect of analogues 4 or 8 (2.5 mg/kg body weight) on blood glucose levels over time were compared to glibenclamide (1 mg/kg body weight) or saline administration. (B) The effect of analogue 8 (2.5 mg/kg body weight) or saline on blood insulin concentrations over time.
