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Kidneys from an obese dog fed a high fat diet for 8 weeks (A) and a severely obese (ob/ob) mouse with leptin deficiency (B). In obese dogs, the fat adheres tightly to the renal capsule, penetrates the renal capsule, and invades the renal sinuses. In obese mice the kidney is surrounded by fat but the fat does not adhere to the kidneys.
