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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Liver Int. 2014 Mar 15;35(4):1145–1151. doi: 10.1111/liv.12507

Figure 4.

Figure 4

BrdU immunohistochemistry following a) PH only or b) PHRT. BrdU incorpaoration is dramatically reduced by RT. c) H&E staining of rat liver 6 weeks after PHRT. Extensive bile ductular proliferation is seen. d) OV-6 immunhistochemistry of rat liver 6 weeks after PHRT confirms ductular and oval cell proliferation. e) H&E staining of rat liver 12 weeks after PHRT+HT. Normal appearing liver parychema is seen. f) In contrast, H&E staining of rat liver 12 weeks after PHRT shows pervenular collapse, pleomorphic nuclei, and extensive bile ductular reaction. g) High power view of DPPIV enzyme histochemist of PHRT +HT rat liver at 12 weeks. DPPIV negative hepatocytes (blue) are seen proliferating in DPPIV positive (orange) parynchyma. h) Low power view indicates approximately 40% repopulation by transplanted hepatocytes.