Figure 1.

CONSORT Diagram detailing participant flow. *Two randomization events – a double-blind 1:1 randomization to tesamorelin vs. placebo, and a 1:1 randomization to euglycemic hyperinsulinemic clamp – occurred simultaneously prior to the baseline visit. These randomization events were independent of each other. Two statistical analyses were performed using (i) an imputation approach to handle missing data and (ii) all available data with missing data treated as missing.