Table 1.
Baseline characteristics stratified by ACEi/ARB
| Un Matched Cohort | Propensity Matched Cohort | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ACEi/ARB (N=1213) |
No ACEi/ARB (N=296) |
ACEi/ARB (N=287) |
No ACEi/ARB (N=287) |
|||||||||
| Variable | Mean | SD | Mean | SD | Diff | p-value | Mean | SD | Mean | SD | Diff | |
| Age (years) | 63 | 12 | 64 | 12 | 8.9% | 0.2 | 65 | 12 | 64 | 12 | 8.1% | |
| Systolic Blood Pressure (mm Hg) | 120 | 19 | 129 | 18 | 2.6% | 0.7 | 120 | 19 | 120 | 18 | 1.8% | |
| Glomerular filtration rate (imputed), (ml/min/1.73m2) | 63 | 20 | 58 | 20 | 25% | <.001 | 60 | 18 | 59 | 19 | 3.6% | |
| Glomerular filtration rate(unimputed), (ml/min/1.73m2) | 64 | 24 | 57 | 23 | 32% | <.001 | 59.0 | 22 | 58 | 23 | 4.4% | |
| Ejection Fraction (%) | 21 | 6 | 20 | 6.0 | 9.0% | 0.2 | 20 | 6 | 20 | 6 | 2.3% | |
| QRS interval (ms) | 136 | 36 | 135 | 33 | 3.0% | 0.7 | 135 | 36 | 136 | 34 | 2.3% | |
| QTC interval (ms) | 472 | 52 | 471 | 54 | 2.7% | 0.6 | 468 | 49 | 471 | 54 | 6.3% | |
| N | % | N | % | Diff | p-value | N | % | N | % | Diff | ||
| Men | 981 | 81% | 230 | 78% | 7.8% | 0.22 | 229 | 80% | 224 | 78% | 4.3% | |
| White | 1035 | 85% | 239 | 81% | 12% | 0.05 | 235 | 82% | 234 | 82% | 0.9% | |
| Age (years) | < 50 | 152 | 13% | 31 | 11% | 6.5% | 0.36 | 28 | 10% | 30 | 11% | 2.3% |
| 50–59 | 296 | 24% | 71 | 24% | 1.0% | 61 | 21% | 69 | 24% | 6.7% | ||
| 60–69 | 407 | 34% | 92 | 31% | 5.3% | 97 | 34% | 88 | 31% | 6.7% | ||
| ≥ 70 | 358 | 30% | 102 | 35% | 11% | 101 | 35% | 100 | 35% | 0.7% | ||
| Body mass index (kg/m2) | <21 | 46 | 4% | 12 | 4% | 1.4% | 0.92 | 8 | 3% | 12 | 4% | 7.6% |
| 21–25 | 194 | 16% | 50 | 17% | 2.4% | 54 | 19% | 49 | 17% | 4.5% | ||
| 25–30 | 512 | 42% | 132 | 45% | 4.8% | 127 | 44% | 129 | 45% | 1.4% | ||
| 30–35 | 286 | 24% | 64 | 22% | 4.7% | 69 | 24% | 60 | 21% | 7.5% | ||
| 35–40 | 120 | 10% | 25 | 8% | 5.0% | 19 | 7% | 25 | 9% | 7.9% | ||
| >40 | 55 | 5% | 13 | 4% | 0.7% | 10 | 4% | 12 | 4% | 3.6% | ||
| Glomerular filtration rate (ml/min/1.73m2) | >60 | 177 | 60% | 845 | 70% | 21% | <.001 | 184 | 64% | 177 | 62% | 5.0% |
| 30–60 | 93 | 31% | 327 | 27% | 9.6% | 87 | 30% | 90 | 31% | 2.3% | ||
| <30 | 26 | 9% | 41 | 3% | 23% | 16 | 6% | 20 | 7% | 6% | ||
| New York Heart Association class | I | 151 | 12% | 52 | 18% | 14% | 0.045 | 42 | 15% | 52 | 18% | 9.4% |
| II | 728 | 60% | 156 | 53% | 15% | 160 | 56% | 152 | 53% | 5.6% | ||
| III | 324 | 27% | 87 | 29% | 6.0% | 85 | 30% | 82 | 29% | 2.3% | ||
| IV | 10 | .8% | 1 | .3% | 6.4% | 0 | 0% | 1 | 0.3% | 8.4% | ||
| Ischemic etiology | 854 | 70% | 221 | 75% | 9.6% | 0.15 | 229 | 80% | 213 | 74% | 13.3% | |
| Device Indications | Secondary | 292 | 24% | 77 | 26% | 4.5% | 0.49 | 74 | 26% | 76 | 27% | 1.6% |
| Defibrillator with biventricular pacing | 523 | 43% | 136 | 46% | 5.7% | 0.38 | 123 | 43% | 131 | 46% | 5.6% | |
| Prior myocardial infarction | 649 | 54% | 169 | 57% | 7.2% | 0.27 | 173 | 60% | 162 | 56% | 7.8% | |
| Diabetes mellitus | 404 | 33% | 116 | 39% | 12% | 0.06 | 119 | 42% | 110 | 38% | 6.4% | |
| Hypertension | 778 | 64% | 181 | 61% | 6.2% | 0.34 | 179 | 62% | 176 | 61% | 2.2% | |
| Hyperlipidemia | 784 | 65% | 188 | 64% | 2.3% | 0.7 | 184 | 64% | 182 | 63% | 1.5% | |
| Smoker | 632 | 52% | 154 | 52% | 0.2% | 0.99 | 149 | 52% | 148 | 52% | 0.70% | |
| Medications | Beta Blockers | 1043 | 86% | 243 | 82% | 11% | 0.09 | 233 | 81% | 238 | 83% | 4.5% |
| Diuretics | 881 | 73% | 207 | 70% | 6.0% | 0.35 | 189 | 66% | 203 | 71% | 10.5% | |
| Aldactone/Eplerenone | 336 | 28% | 69 | 23% | 10% | 0.13 | 69 | 24% | 68 | 24% | 0.82% | |
| Digoxin | 572 | 47% | 107 | 36% | 23% | 0.001 | 108 | 38% | 105 | 37% | 2.2% | |
| Anti-Arrhythmics | 249 | 21% | 63 | 21% | 1.9% | 0.77 | 62 | 22% | 62 | 22% | 0.0% | |
| Amiodarone | 194 | 16% | 55 | 19% | 6.9% | 0.28 | 51 | 18% | 54 | 19% | 2.7% | |
Diabetes mellitus was defined as fasting blood glucose >126 mg/dl or HbA1c ≥6.5 or taking hypoglycemic agents or insulin. Hypertension was defined as systolic blood pressure >140 mm Hg or diastolic blood pressure >90 mm Hg or taking anti-hypertensive medication. Hyperlipidemia was defined as elevated total cholesterol or low-density lipoprotein levels above the goals set by the ATPIII or taking cholesterol lowering agents.