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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Biochim Biophys Acta. 2015 Jan 24;1851(5):527–536. doi: 10.1016/j.bbalip.2015.01.012

Figure 4. Hepatic cholesterol and proteins with a role in cholesterol homeostasis in SNTA/B2−/− (A/B−/−) mice fed a HFD.

Figure 4

(A) Liver cholesterol (Chol) measured with a commercial assay and normalized to total protein in 8 WT and 8 SNTA/B2−/− mice fed a HFD for 25 weeks. (B) SREBP2 mRNA in the liver of 8 WT and 7 SNTA/B2−/− mice fed a HFD for 25 weeks. (C) Active SREBP2 protein in the liver (D) Quantification of active SREBP2 protein in the liver of 7 WT and 7 SNTA/B2−/− mice fed a HFD for 25 weeks. (E) HMG-CoA-R mRNA in the liver of 8 WT and 7 SNTA/B2−/− mice fed a HFD for 25 weeks. (F) LDL-R mRNA in the liver of these mice. (G) pAMPK, AMPK and caveolin-1 in the liver of a wild type and a SNTA/B2 null mouse. (H) AKT and chemerin in the liver of a wild type and a SNTA/B2 null mouse.