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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Bioorg Med Chem. 2015 Feb 7;23(7):1588–1600. doi: 10.1016/j.bmc.2015.01.060

Scheme 2.

Scheme 2

S ynthesis of racemic trans 4-(biphenyl-3-yl) N,N-dimethylaminotetralin (5n); Reagents and conditions: (a) PhB(OH)2, Pd(OAc)2, (c-Hex)2P(biphen-3-yl), K3PO4/toluene, 65 °C, 24 h; (b) NaBH4/MeOH, 50 °C,15 h; (c) TsCl/pyridine, rt, 20 h; (d) aq. NHMe2, sealed tube, 80 °C, 24 h.