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. 2015 Feb 26;17(1):37. doi: 10.1186/s13075-015-0550-4

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© Pineda et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Histopathological analysis of rabbit knee joint injected with monosodium urate (MSU), allopurinol and control groups. Hypertrophy, inflammatory cell infiltration and MSU crystal aggregates (arrows) were present in the synovium starting from day 1. No cartilage abnormalities were observed at any time points.