Table 1.

Autoimmune encephalitis with antibodies against cell surface and synaptic proteins

Antigen	Clinical syndrome	Tumor
NMDAR (GluN1)	Anti-NMDAR encephalitis: prodromal symptoms, psychiatric, seizures, amnesia, movement disorders, catatonia, autonomic instability, coma	Age-dependent 10–45% ovarian teratomas, infrequently carcinomas
AMPAR	Limbic encephalitis, psychiatric symptoms	70% (lung, breast, thymoma)
GABAbR	Limbic encephalitis, prominent seizures	50% lung, neuroendocrine
LGI1	Limbic encephalitis, 60% hyponatremia, occasional focal faciobrachial seizures prior to encephalitis	<10% (lung, thymoma)
CASPR2	Encephalitis, Morvan syndrome, neuromyotonia	0–40% thymoma
mGluR5	Limbic encephalitis (reported in less than 10 patients)	Frequently, Hodgkin lymphoma
D2R	Basal ganglia encephalitis, Sydenham chorea.	Infrequent
DPPX	Diarrhea, encephalitis with CNS hyperexcitability: confusion, psychiatric symptoms, tremor, myoclonus, nystagmus, hyperekplexia, PERM-like symptoms, ataxia.	No tumor association
GABAaR	Refractory seizures, status epilepticus, or epilepsia partialis continua, stiff-person, opsoclonus	Infrequent
GlyR	Stiff-person, PERM, limbic encephalitis, cerebellar degeneration, optic neuritis	Infrequent
IgLON5	Abnormal sleep movements and behaviors,obstructive sleep apnea, stridor, dysarthria, dysphagia, ataxia, chorea (reported in less than 10 patients)	No tumor association