(A) Summary of protein quality control mechanisms in ASH. Levels of Mca1, Hsp104, Hsp40, Ydj1, VCP/p97 and p62 were found to be elevated in ASH. These are involved in all four protein quality control mechanisms discussed: autophagy, the ERAD, the JUNQ and the IPOD systems. (B) Summary of protein quality control mechanisms in NASH. Only Ssa1 and Hsp104, associated with autophagy and the IPOD system, respectively, were found to be elevated in NASH specimens. Our data suggests that different protein quality control mechanisms are utilized in ASH versus NASH.