Table 2.
Patient outcomes with ABO matched or ABO mismatched grafts (all diagnoses).
| Event | ABO Matched | ABO Minor MM | ABO Major MM | ABO Bidir MM |
|---|---|---|---|---|
| Total patients | 1053 | 297 | 305 | 78 |
| Overall survival, y, median | 6.3 | 2.1 | 5.87 | NR |
| Number of events | 526 | 167 | 153 | 32 |
| HR (c.i.) | 1 | 1.27 (1.07 - 1.52) | 0.98 (0.82 - 1.18) | 0.8 (0.56 - 1.5) |
| P-value | – | 0.005 | 0.87 | 0.22 |
| EFS, y, median | 2.7 | 1.2 | 2.08 | 7.27 |
| Number of events | 606 | 183 | 180 | 37 |
| HR (c.i.) | 1 | 1.2 (1.02 - 1.42) | 1.02 (0.86 - 1.21) | 0.8 (0.57 - 1.11) |
| P-value | – | 0.028 | 0.81 | 0.18 |
| Relapse | ||||
| Number of events | 328 | 89 | 107 | 20 |
| HR (c.i.) | 1 | 1.09 (0.86 - 1.37) | 1.12 (0.9 - 1.4) | 0.78 (0.5 - 1.23) |
| P-value | – | 0.49 | 0.3 | 0.29 |
| NRM, overall | ||||
| Number of events | 278 | 94 | 73 | 17 |
| HR (c.i.) | 1 | 1.34 (1.06 - 1.69) | 0.89 (0.69 - 1.15) | 0.82 (0.5 - 1.34) |
| P-value | – | 0.015 | 0.38 | 0.42 |
| NRM, day 100 | ||||
| Events @ d100 | 137 | 53 | 25 | 5 |
| HR (c.i.) | 1 | 1.41 (1.03 - 1.94) | 0.62 (0.4 - 0.95) | 0.48 (0.2 - 1.18) |
| P-value | – | 0.033 | 0.027 | 0.11 |
| aGVHD, gr2-4 | ||||
| Events @ d125 | 220 | 72 | 61 | 14 |
| HR (c.i.) | 1 | 1.26 (0.96 - 1.64) | 0.95 (0.72 - 1.26) | 0.87 (0.51 - 1.49) |
| P-value | – | 0.094 | 0.73 | 0.6 |
| aGVHD, gr3-4 | ||||
| Events @ d125 | 166 | 35 | 29 | 10 |
| HR (c.i.) | 1 | 1.14 (0.78 - 1.67) | 0.77 (0.51 - 1.17) | 1.22 (0.64 - 2.3) |
| P-value | – | 0.49 | 0.23 | 0.55 |