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. 2015 Mar 18;35(11):4540–4551. doi: 10.1523/JNEUROSCI.4825-14.2015

Figure 6.

Figure 6.

cAMP and Src kinase activities are involved in the serotonergic signaling. A, Left, Application of 10 μm 5-HT induced an inward current. Right, Twenty minute bath application of 1 mm 8-Br-cAMP, a membrane-permeable cAMP analog, largely blocked this inward current. B, C, Left, Preincubation of PP1 or PP2, selective Src kinase inhibitors, for >1 h, application of 10 μm 5-HT induced a small inward current. Right, After 1 h washout of PP1 and PP2 (20 μM), application of 5-HT induced a larger inward current. D–F, Pooled data showing the 5-HT-evoked current in the presence and absence of 8-Br-cAMP (n = 8), PP1 (n = 7), and PP2 (n = 6). Bars are mean ± SEM.