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. 2015 Mar 10;15:112. doi: 10.1186/s12885-015-1091-6

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© Fung et al.; licensee BioMed Central. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The number of total (CD31+) and functional (DiOC7+) blood vessels (per tumor area), and the percentage of functional blood vessels present in untreated MCF-7 subcutaneous or orthotopic xenografts. Bars represent the mean of 2-12 tumors; error bars represent standard error of the mean (SEM). Scale – numeric values represent number of blood vessels per unit area (x10⁶) for the left and middle panels, and percent functional blood vessels for the right panel. Symbols represent statistical significance between subcutaneous and orthotopic tumors for functional (*) and percent functional (♦) blood vessels.