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. 2015 Mar 10;15:112. doi: 10.1186/s12885-015-1091-6

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© Fung et al.; licensee BioMed Central. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Effect of paclitaxel on tumor vasculature in MCF-7 xenografts. The number of total (CD31+) and functional (DiOC7+) blood vessels per tumor area (left panels), and the percentage of functional blood vessels (right panels) present on Day 0, 2, 4, 8, and 12 in MCF-7 A) subcutaneous xenografts or B) orthotopic xenografts following a single dose of paclitaxel (25 mg/kg, administered intraperitoneally). C) The number of total (CD31+) and functional (DiOC7+) blood vessels (per tumor area), and the percentage of functional blood vessels present in Day 12 MCF-7 subcutaneous or orthotopic xenografts. Bars represent the mean of 2-12 tumors; error bars represent standard error of the mean (SEM). Symbols represent statistical significance for total (*), functional (♦) and percent functional (+) blood vessels as compared to control (Day 0) tumors.