Table 1.
Tumor area as measured by number of pixels (x10 7 ) for A431 xenografts, and ectopic or orthotopic MCF-7 xenografts taken on Day 0 (untreated), 2, 4, 8, or 12 following a single dose of paclitaxel (25 mg/kg, i.p.), doxorubicin (DOX 8 mg/kg, i.v.), or 5-FU (100 mg/kg, i.p.)
| Day | A431 | MCF-7 Paclitaxel | MCF-7 DOX | MCF-7 5-FU | |||||
|---|---|---|---|---|---|---|---|---|---|
| Paclitaxel | DOX | 5-FU | SC | Ortho | SC | Ortho | SC | Ortho | |
| 0 | 1.18 (0.27) | 2.29 (0.25) | 2.29 (0.25) | 4.79 (0.65) | 7.40 (4.60) | 4.79 (0.65) | 7.40 (4.60) | 4.79 (0.65) | 7.40 (4.60) |
| 2 | ______ | 2.43 (0.38) | 1.96 (0.19) | ______ | 3.25 (1.41) | 6.99 (0.91) | 2.53 (0.55) | 7.27 (1.16) | 5.34 (1.24) |
| 4 | 1.67 (0.16) | 2.70 (0.49) | 2.71 (0.49) | 3.94 (0.61) | 5.04 (1.41) | 4.86 (1.33) | 3.29 (---) | 1.27 (0.53)* | 4.49 (2.08) |
| 8 | 0.99 (0.15) | 2.42 (0.36) | 1.92 (0.32) | 3.78 (0.47) | 5.20 (0.80) | 3.39 (0.63) | 4.06 (1.35) | 5.11 (1.17) | 5.85 (0.76) |
| 12 | 0.47 (0.06)* | 2.11 (0.47) | 1.27 (0.37) | 4.57 (0.33) | 2.05 (0.82) | 3.17 (0.65) | ______ | 3.34 (0.85) | 7.48 (0.83) |
Symbols (*) represent statistically significant differences in tumor area compared to control tumors (P < 0.05).