FIG 4.

MyD88 is necessary for timely recruitment and activation of T cells and NK cells. (A) Analysis of global cytokine production in the lungs of Histoplasma-infected mice for total IFN-γ and IL-17A. (B to E) Analysis of lung cell counts and percent cells expressing CD69 for γδ TCR⁺ cells (B), NK cells (C), CD8⁺ T cells (D), and CD4⁺ T cells (E). CD4⁺ T cells are defined as CD45⁺ CD3ε⁺ CD4⁺ cells. CD8⁺ T cells are defined as CD45⁺ CD3ε⁺ CD8⁺ cells. γδ TCR⁺ cells are defined as CD45⁺ CD3ε⁺ γδ TCR⁺ cells. NK cells are defined as CD45⁺ CD3ε⁻ NK1.1⁺ cells. *, P < 0.05; **, P < 0.01; ***, P < 0.001; P values were determined by ANOVA.