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. 2015 Mar 17;83(4):1695–1704. doi: 10.1128/IAI.03138-14

FIG 4.

FIG 4

PIK3C2A is required in primary infected cells for VLP formation in HT-29 cells. Graphs showing the relative proportion of protrusions (Protrusions) and vacuole-like protrusions (VLP) in mock-treated (Mock) (A), PIK3C2A-depleted (PIK3C2A KD) (B), and PIK3C2A-depleted (C) HT-29 cells transfected with an RNAi-resistant construct (PIK3C2A res). Values represent the mean of 3 independent experiments. Statistical analysis: PIK3C2A KD versus Mock (VLP), P < 0.0001; PIK3C2A KD versus PIK3C2A res (VLP), P < 0.0005; unpaired t test.