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. 2015 Jan 29;12(1):3. doi: 10.1186/1559-0275-12-3

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© Li et al.; licensee BioMed Central. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Overview of experimental variations and control methods. (A) Exemplar sources of variations. Systematic variations affect all proteins or peptides similarly. Protein- or peptide-specific variations affect only particular proteins or peptides. Random variations are not listed because they are not controllable. (B) Control of variations by different quantification methods in the analysis of plasma samples on a depletion-MRM-MS platform. (C) Overview of the three assessment studies and the combined HPS dataset.