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. Author manuscript; available in PMC: 2015 Apr 28.
Published in final edited form as: Cancer Lett. 2013 Dec 22;346(1):114–121. doi: 10.1016/j.canlet.2013.12.020

Fig. 2.

Fig. 2

IDH1 up-regulation suppressed cell proliferation. (A) IDH1 protein increased significantly in 143B OE cells and decreased significantly in 143B KD cells, compared with EV cells. Same results were found in MG63 cells. No significant difference was found on IDH1 protein expression between NT cells and EV cells in 143B or MG63. β-actin was monitored as the control. Representative western blotting result was shown (a and b). OE: up-regulation of IDH1; KD: down-regulation of IDH1; EV: empty lentivector treated; NT: nonlentivector treated. (B) Up-regulated IDH1 inhibited cell proliferation in 143B OE cells or MG63 OE cells, compared with in control EV cells (a and b). Whereas down-regulated IDH1 showed opposite result in either 143B or MG63 (a and b). (C) IDH1 showed the same tendency in cell colony formation as in cell growth curve *P < 0.05; **P < 0.01.