Table 2. Summary of reversion within CTL epitopes following transmission in the presence or absence of the selecting HLA type.
PID | Days PI | Optimal epitope a | Restricting HLA | HLA-association b |
---|---|---|---|---|
AS2–0016 | EWDRLHPVHAGPIAPGQMR | B*42 | + | |
14 | ....T.............. | |||
463 | ................... | |||
MQMLKDTINEEAAEWDRLHP | B*57 | − | ||
14 | .................T.. | |||
463 | .................... | |||
AS2–0341 | MVHQAISPRTLNAWVKVIE | B*57/B*58 | + | |
14 | ....P.............. | |||
342 | ................... | |||
LQGQMVHQAISPRTLNAWVK | B*1510 | − | ||
14 | ........P........... | |||
342 | .................... | |||
SQNYPIVQNLQGQMVHQAI | C*16 | − | ||
14 | .................P. | |||
342 | ................... | |||
AS2–1037 | GTEELRSLYNTVATLYCVHEK | A*3002 | − | |
34 | ........F..T.......AR | |||
321 | ..................... | |||
EELRSLYNTVATLYCVHEK | A*29 | − | ||
34 | ......F..T.......AR | |||
321 | ................... | |||
TEELRSLYNTVATLYCVHE | A*02 | − | ||
34 | .......F..T.......A | |||
321 | ................... |
aBold residues denotes known CTL escape mutation
b(+): presence of HLA-association, (−): absence of previously identified HLA association
Underlining denotes the CTL epitope in the peptide sequence