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. 2015 Mar 17;10(3):e0119832. doi: 10.1371/journal.pone.0119832

Fig 2. Suppression of MET and AXL by AUY922 in resistant cell lines.

Fig 2

A, Cells were treated with the indicated doses of AUY922 for 72 hours in medium containing 1% FBS. Attached cells were stained with trypan blue solution (top). Cell viability based on cell counting is also shown (bottom). Bars represent the mean ±SD of three wells. B, Cells treated with AUY922, similar to panel A. After 48 hours, cells were harvested and EGFR-related signaling molecules were evaluated using western blotting. C, LK2 cells were treated with vector-containing wild-type EGFR, del E746-E750, MET, or AXL and the indicated doses of AUY922 for 12 hours.