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. 2015 Mar 17;10(3):e0119832. doi: 10.1371/journal.pone.0119832

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Fig 4 — A, SCID mice with established HCC827/GR and HCC827/ER tumor cell xenografts were treated with AUY922. Tumor size was measured on the indicated days, and tumor volume was calculated. Arrows mean last day of drug treatment (red arrow, HCC827/GR; purple arrow, HCC827/ER). Bars represent the mean tumor volume ± SD. B and C, Immunohistochemical staining for Ki-67 and TUNEL followed by quantitative analysis of proliferation and apoptosis in (B) Ki-67⁺ cells and (C) TUNEL⁺ cells. *p< 0.01 and **p< 0.001 in comparison with the control.