Table 3.
Stratified analyses of the IL-1β-511C/T polymorphism on asthma risk in meta-analysis.
| N a | Case/control | CC versus TT | TC versus TT | CC/TC versus TT | CC versus TC/CC | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P b | OR (95% CI) | P b | OR (95% CI) | P b | OR (95% CI) | P b | |||
| Total | 10 | 1385/1964 | 1.12 [0.96, 1.32] | 0.15 | 1.10 [0.98, 1.21] | 0.10 | 1.11 [0.91, 1.25] | 0.06 | 1.10 [0.93, 1.31] | 0.11 |
| Ethnicities | ||||||||||
| Asian | 5 | 748/1018 | 1.05 [0.78, 1.41] | 0.77 | 1.02 [0.80, 1.29] | 0.97 | 1.03 [0.82, 1.28] | 0.96 | 1.03 [0.80, 1.33] | 0.68 |
| Caucasian | 5 | 637/946 | 1.24 [0.88, 1.76] | 0.11 | 1.19 [0.94, 1.52] | 0.006C | 1.20 [0.95, 1.52] | 0.01C | 1.06 [0.78, 1.44] | 0.03C |
| Source of control | ||||||||||
| PB | 4 | 597/806 | 1.29 [0.90, 1.84] | 0.81 | 1.14 [0.91, 1.43] | 0.05 | 1.11 [0.86, 1.41] | 0.05 | 1.04 [0.91, 1.20] | 0.18 |
| HB | 6 | 788/1158 | 1.03 [0.77, 1.37] | 0.81 | 1.07 [0.82, 1.38] | 0.14 | 1.13 [0.91, 1.39] | 0.26 | 0.95 [0.74, 1.22] | 0.23 |
| Mean of age | ||||||||||
| Adult | 6 | 830/1277 | 1.03 [0.78, 1.35] | 0.86 | 1.04 [0.85, 1.28] | 0.03C | 1.05 [0.06, 1.27] | 0.10 | 0.98 [0.77, 1.24] | 0.24 |
| Childhood | 4 | 555/687 | 1.35 [0.90, 2.40] | 0.05 | 1.24 [0.93, 1.66] | 0.41 | 1.26 [0.95, 1.67] | 0.30 | 1.24 [0.88, 1.75] | 0.18 |
N a: number of comparisons.
P b: value of Q-test for heterogeneity test.
CRandom effects model was used when P value for heterogeneity test <0.05; otherwise, fixed effects model was used.