Table 2. Comparison of wild type (WT) and Cox2 KO mice.

Parameter	Number	WT mice	Cox2 KO mice
Weight (g)	28	26.7 ± 0.19	24.0 ± 0.12 a
BMD (mg/mm2)	28	65.6 ± 0.66	62.4 ± 0. 35 a
Body fat (%)	15	15.7 ± 0.11	13.0 ± 0.10 a
Lean mass (g)	15	20.5 ± 0.19	20.0 ± 0.12
Femur length (mm)	13	15.3 ± 0.05	15.3 ± 0.08

Mice from both 12-d and 21-d infusion studies were pooled for weight, BMD, and femur length. Lean mass and % fat were measured only in the 12-d study. Except for femur length, which was measured on vehicle-treated mice at the end of infusion, all other parameters were measured 1 day prior to beginning infusion. Data are means ± SEM for (n) mice.

^aSignificant effect of genotype, p<0.01. BMD, % fat and lean mass were measured in vivo by DXA. Femur lengths were measured ex vivo by μCT.