Table 3. Body weight, serum calcium (Ca) and serum PGE2 in wild type (WT) and Cox2 KO mice infused with vehicle or PTH for 12 days.
| Parameter | WT mice | Cox2 KO mice | ||
|---|---|---|---|---|
| Vehicle | PTH | Vehicle | PTH | |
| Start weight (g) | 27.3 ± 0.26 (7) | 27.0 ± 0.63 (8) | 24.1 ± 0.18 b (7) | 24.2 ± 0.18 b (8) |
| End weight (g) | 28.9 ± 0.32 (7) | 28.4 ± 0.30 (8) | 25.7 ± 0.18 b (7) | 25.9 ± 0.18 b (8) |
| Ca (mg/dl) at end | 9.8 ± 0.11 (7) | 12.1 ± 0.17 a (8) | 9.8 ± 0.07 (7) | 11.9 ± 0.10 a (8) |
| PGE2 (pg/ml) at end | 5.2 ± 1.37 (3)* | 127.7 ± 13.80 a (6) | UD (6) | UD (6) |
Data are means ± SEM for (n) mice.
aSignificant effect of PTH, p<0.01.
bSignificant effect of genotype, p<0.01.
*Three of the 6 samples were below the limit of detectability of the assay (3.25 pg/ml) and the mean was calculated from the remaining 3 samples. Hence, the value is an overestimate of true value. UD = undetectable. 352 pg/ml = 1 nM PGE2