Table 4. Cortical morphometry by μCT in the midshaft femoral region of WT and Cox2 KO mice after infusion with vehicle or PTH for 12 days.
Parameter | WT mice | Cox2 KO mice | ||
---|---|---|---|---|
Vehicle (7) | PTH (8) | Vehicle (7) | PTH (8) | |
Cortical area (mm2) | 1.02 ± 0.03 | 0.97 ± 0.03 | 0.98 ± 0.02 | 1.23 ± 0.07 a , b |
Cortical thickness (mm) | 0.21 ± 0.01 | 0.19 ± 0.01 | 0.20 ± 0.01 | 0.25 ± 0.01 a , b |
Cortical porosity (%) | 0.55 ± 0.09 | 0.56 ± 0.07 | 0.57 ± 0.07 | 0.39 ± 0.03 |
Subperiosteal area (mm2) | 2.17 ± 0.03 | 2.08 ± 0.06 | 2.23 ± 0.04 | 2.43 ± 0.14 |
Subendosteal area (mm2) | 1.15 ± 0.02 | 1.11 ± 0.04 | 1.25 ± 0.04 | 1.20 ± 0.09 |
Data are means ± SEM for (n) mice.
aSignificant effect of PTH, p<0.01.
bSignificant effect of genotype, p<0.05.