Table 6. Cortical morphometry by μCT in the midshaft femoral region of WT and Cox2 KO mice after infusion with vehicle or PTH for 21 days.
Parameter | WT mice | Cox2 KO mice | ||
---|---|---|---|---|
Vehicle (6) | PTH (7) | Vehicle (6) | PTH (7) | |
Cortical area (mm2) | 0.94 ± 0.02 | 0.91 ± 0.02 | 0.88 ± 0.03 | 1.05 ± 0.03 a , b |
Cortical thickness (mm) | 0.21 ± 0.01 | 0.20 ± 0.01 | 0.20 ± 0.01 | 0.19 ± 0.01 |
Cortical porosity (%) | 0.33 ± 0.06 | 0.31 ± 0.04 | 0.53 ± 0.11 | 1.05 ± 0.46 |
Subperiosteal area (mm2) | 1.97 ± 0.05 | 2.12 ± 0.07 | 1.89 ± 0.04 | 1.92 ± 0.04 |
Subendosteal area (mm2) | 1.03 ± 0.04 | 1.16 ± 0.06 | 1.01 ± 0.03 | 1.06 ± 0.03 |
Data are means ± SEM for (n) mice.
aSignificant effect of PTH, p<0.01.
bSignificant effect of genotype, p<0.05.