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. 2015 Feb 4;38(3):251–258. doi: 10.14348/molcells.2015.2302

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Fig. 5. — The p53 pathway is activated in T cells of [Brca2^F11/F11; Lck-Cre] mice. Western blot analysis was performed on the thymic (A) and CD4⁺ splenic T cells as fresh (B) or 48 h after anti-CD3 and anti-CD28 antibody stimulation (C), from the WT and [Brca2^F11/F11; Lck-Cre] mice. Actin was used as a loading control. Signals for p53 phosphorylation (mouse pSer18) were detectable only in activated T cells. Western blot data were quantified by densitometry and normalized by Actin signals (bar graphs on the right). On the bar graphs, Y axis is an arbitrary unit and each bar represents average +/− SD from 3 mice. The p values < 0.05 are marked as asterisks.