Figure 1.

Summary model representing stimulation of the NF-κB pathway leading to the classical pathway, followed by expression of NF-κB dependent proteins. Analogous inflammatory stimuli are common amongst esophageal, gastric and colorectal tissue. The unique stimuli commonly induce inflammation. The classic pathway is displayed and this model would be consistent with the alternate pathway. An array of genes are transcribed and translated contributing to the carcinogenesis. ROS: Reactive oxygen species.