Table 3.
Multivariate analysis of prognostic factors in patients with intrahepatic cholangiocarcinoma
| Parameters | HR | 95%CI | P value |
| Node stage | |||
| Negative | 1.000 | ||
| Positive | 3.166 | 1.108-9.046 | 0.031 |
| Tumor size (cm) | |||
| < 5 | 1.000 | ||
| ≥ 5 | 4.212 | 1.429-12.420 | 0.009 |
| Microvascular invasion | |||
| Negative | 1.000 | ||
| Positive | 2.730 | 1.088-6.850 | 0.032 |
| HMGB1 | |||
| Negative | 1.000 | ||
| Positive | 4.517 | 1.458-13.992 | 0.009 |
| VEGF-C | |||
| Negative | 1.000 | ||
| Positive | 3.003 | 1.016-8.875 | 0.047 |
HMGB1: High-mobility group box 1; HR: Hazard ratio; VEGF-C: Vascular endothelial growth factor C.