Table 4.
Factors associated with recurrence-free survival: Multivariate analysis
| Factor |
No PCRT |
PCRT |
||||
| HR | 95%CI | P value | HR | 95%CI | P value | |
| p/yp N category | < 0.001 | 0.380 | ||||
| N1 | 1.00 | 1.00 | ||||
| N2 | 1.90 | 1.43-2.53 | 1.21 | 0.79-1.85 | ||
| LNR category | < 0.001 | 0.001 | ||||
| LNR1 | 1.00 | 1.00 | ||||
| LNR2 | 1.97 | 1.48-2.63 | 1.94 | 1.31-2.88 | ||
| Lymphovascular invasion | 0.34 | |||||
| None | 1.00 | 1.00 | 0.110 | |||
| Present | 1.24 | 0.93-1.67 | 1.42 | 0.89-2.27 | ||
| Perineural invasion | 0.04 | 0.030 | ||||
| None | 1.00 | 1.00 | ||||
| Undetermined | 1.65 | 1.12-2.43 | 1.86 | 1.18-2.93 | ||
| Location | 0.02 | 0.040 | ||||
| 6-10 cm | 1.00 | 1.00 | ||||
| ≤ 5 cm | 1.34 | 1.05-1.85 | 0.62 | 0.40-0.98 | ||
| Preoperative CEA | 0.02 | |||||
| Normal | 1.00 | |||||
| Increased | 1.46 | 1.07-1.98 | ||||
PCRT: Preoperative chemoradiotherapy; LNR: Lymph node ratio; CEA: Carcinoembryoinc antigen.