Table 1. In- vitro antifungal susceptibility profile of Aspergillus terreus and A. hortai isolates (n = 140) from India against medical triazoles, echinocandins and amphotericin B.
| Species tested | MIC/MEC# parameters (mg/L)* | Drugs # | |||||||
|---|---|---|---|---|---|---|---|---|---|
| ITC | VRC | ISA | POS | AMB | CFG $ | MFG $ | AFG $ | ||
| A. terreus (n = 138) | GM | 0.23 | 0.40 | 0.21 | 0.07 | 2.97 | 0.048 | 0.015 | 0.016 |
| MIC50/MEC50 $ | 0.25 | 0.5 | 0.25 | 0.06 | 2 | 0.06 | 0.015 | 0.015 | |
| MIC90/MEC90 $ | 0.5 | 0.5 | 0.5 | 0.25 | 8 | 0.125 | 0.015 | 0.015 | |
| Range | 0.03–2 | 0.25–1 | 0.06–2 | 0.015–1 | 0.5–16 | 0.015–1 | 0.015–0.03 | 0.015–0.125 | |
| A. hortai (n = 2) | Range | 0.25–0.5 | 0.5 | 0.25–0.5 | 0.06–0.25 | 4–16 | 0.015–0.06 | 0.015 | 0.015 |
*MIC, minimum inhibitory concentration; MEC, minimum effective concentration was recorded for 3 echinocandins; GM, geometric mean; MIC50 andMIC90, MIC at which 50% and 90% of test isolates were inhibited respectively.
$MEC50 and MEC90, MEC at which 50% and 90% of test isolates revealed the growth of small, rounded, degenerated hyphae respectively.
#ITC, itraconazole; VRC, voriconazole; ISA, isavuconazole; POS, posaconazole; AMB, amphotericin B; CFG, caspofungin; MFG, micafungin; AFG, anidulafungin