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. 2015 Mar 17;10(3):e0118997. doi: 10.1371/journal.pone.0118997

Table 1. In- vitro antifungal susceptibility profile of Aspergillus terreus and A. hortai isolates (n = 140) from India against medical triazoles, echinocandins and amphotericin B.

Species tested MIC/MEC# parameters (mg/L)* Drugs #
ITC VRC ISA POS AMB CFG $ MFG $ AFG $
A. terreus (n = 138) GM 0.23 0.40 0.21 0.07 2.97 0.048 0.015 0.016
MIC50/MEC50 $ 0.25 0.5 0.25 0.06 2 0.06 0.015 0.015
MIC90/MEC90 $ 0.5 0.5 0.5 0.25 8 0.125 0.015 0.015
Range 0.03–2 0.25–1 0.06–2 0.015–1 0.5–16 0.015–1 0.015–0.03 0.015–0.125
A. hortai (n = 2) Range 0.25–0.5 0.5 0.25–0.5 0.06–0.25 4–16 0.015–0.06 0.015 0.015

*MIC, minimum inhibitory concentration; MEC, minimum effective concentration was recorded for 3 echinocandins; GM, geometric mean; MIC50 andMIC90, MIC at which 50% and 90% of test isolates were inhibited respectively.

$MEC50 and MEC90, MEC at which 50% and 90% of test isolates revealed the growth of small, rounded, degenerated hyphae respectively.

#ITC, itraconazole; VRC, voriconazole; ISA, isavuconazole; POS, posaconazole; AMB, amphotericin B; CFG, caspofungin; MFG, micafungin; AFG, anidulafungin