Fig 4. NKX3.1-loss in patients harboring ERG rearrangements is not predictive of biochemical relapse.

Patient data from Taylor et al. [29] was used to compare via Kaplan-Meier analysis the disease-free survival of patients overexpressing ERG, which is highly predictive of harboring TMPRSS2-ERG fusion. Within this 'ERGup' cohort, patients who exhibited NKX3.1 downregulation (red line, n = 4) compared to those who expressed normal levels of NKX3.1 (blue line, n = 65) were not more likely to display biochemical relapse. Logrank test p value was 0.35. Analysis performed using the cbioportal software [31].