Figure 5.
AQP1 blockade results in no difference in tumour size in H226 tumours in a subcutaneous xenograft model of MM. (a) A pattern towards an early decrease in tumour size was noted in the initial dose-finding experiment: DMSO, n = 5; 20 μM AqB050, n = 6; 80 μM AqB050, n = 6, P = 0.334. (b) A longer follow-up experiment using the dose with the highest potential for improved response confirmed no significant difference in tumor growth: untreated, n = 6; 20 μM AqB050, n = 5; DMSO, n = 7, P = 0.761. Analysis by repeated measures ANOVA; error bars = SEM.