. 2015 Mar 17;10(3):e0117692. doi: 10.1371/journal.pone.0117692

Table 4. Longitudinal ROI-based analysis.

			BASELINE VS MONTH24
ROI			CIVET									FREESURFER
			CTR		sMCI		pMCI		AD		ANOVA P-value	CTR		sMCI		pMCI		AD		ANOVA P-value
			△ MEAN (mm) ± σ								ANOVA P-value	△ MEAN (mm) ± σ								ANOVA P-value
3	*Frontal*	Superior Frontal Gyrus	0.00	0.08	−0.04	0.12	−0.10	0.12	−0.13 ^¥	^⊙ 0.12	<0.0001	−0.04	0.10	−0.06	0.13	−0.12	0.14	−0.13 ^¥	0.12	0.0002
4		Middle Frontal Gyrus	−0.03	0.06	−0.05	0.10	−0.11 ^¢	0.12	−0.13 ^¥	^⊙ 0.12	<0.0001	−0.04	0.08	−0.06	0.13	−0.09	0.12	−0.11 ^¥	0.13	0.0031
5		Inferior Frontal Gyrus, pars triangularis	−0.03	0.08	−0.03	0.11	−0.12 ^¢	^Ξ 0.11	−0.15 ^¥	^⊙ 0.13	<0.0001	−0.04	0.08	−0.05	0.15	−0.07	0.10	−0.09	0.11	N.S.
6		Inferior Frontal Gyrus, pars opercularis	−0.02	0.07	−0.04	0.10	−0.11 ^¢	0.10	−0.14 ^¥	^⊙ 0.12	<0.0001	−0.05	0.11	−0.05	0.15	−0.07	0.12	−0.11	0.11	N.S.
33		Frontal Orbital Cortex	−0.12	0.10	−0.03	0.15	−0.11 ^¢	0.14	−0.15 ^¥	^⊙ 0.16	<0.0001	−0.04	0.07	−0.05	0.11	−0.08	0.11	−0.10 ^¥	0.09	0.0011
18	*Parietal*	Superior Parietal Lobule	−0.03	0.09	−0.02	0.10	−0.06	0.11	−0.09 ^¥	^⊙ 0.10	0.0006	−0.05	0.10	−0.05	0.14	−0.06	0.11	−0.08	0.10	N.S.
19		Supramarginal Gyrus, anterior division	−0.03	0.65	−0.04	0.09	−0.10 ^¢	0.10	−0.12 ^¥	^⊙ 0.11	<0.0001	−0.05	0.11	−0.04	0.10	−0.09	0.13	−0.12 ^¥	0.12	0.0022
20		Supramarginal Gyrus, posterior division	−0.04	0.07	−0.05	0.10	−0.12 ^¢	0.10	−0.14 ^¥	^⊙ 0.11	<0.0001	−0.05	0.09	−0.05	0.12	−0.09	0.12	−0.12 ^¥	^⊙ 0.11	0.0010
31		Precuneus Cortex	−0.01	0.07	−0.02	0.07	−0.07	0.11	−0.11 ^¥	^⊙ 0.11	<0.0001	−0.05	0.08	−0.03	0.07	−0.09	0.10	−0.11 ^¥	^⊙ 0.10	<0.0001
22	*Ocp.*	Lateral Occipital Cortex, superior division	−0.03	0.07	−0.02	0.09	−0.09	^Ξ 0.09	−0.11 ^¥	^⊙ 0.11	<0.0001	−0.04	0.10	−0.06	0.13	−0.12	0.14	−0.13 ^¥	0.12	0.0002
23	*Ocp.*	Lateral Occipital Coitex, inferior division	−0.03	0.09	−0.03	0.11	−0.12 ^¢	0.11	−0.15 ^¥	^⊙ 0.15	<0.0001	−0.06	0.07	−0.05	0.10	−0.10	0.10	−0.07	0.09	N.S.
29	*Lmb.*	Cingulate Gyrus, anterior division	0.00	0.08	0.01	0.13	−0.04	0.12	−0.11 ^¥	^⊙ 0.14	<0.0001	−0.02	0.07	−0.04	0.11	−0.07	0.08	−0.08 ^¥	0.09	0.0024
30	*Lmb.*	Cingulate Gyrus, posterior division	−0.01	0.10	−0.02	0.07	−0.07	0.16	−0.12 ^¥	^⊙ 0.12	<0.0001	−0.04	0.06	−0.04	0.07	−0.10 ^¢	0.11	−0.11 ^¥	^⊙ 0.09	<0.0001
8	*Temporal*	Temporal Pole	−0.04	0.11	−0.05	0.19	−0.20 ^¢	0.17	−0.27 ^¥	^⊙ 0.29	<0.0001	−0.06	0.07	−0.09	0.11	−0.13	0.15	−0.18 ^¥	0.14	<0.0001
9		Superior Temporal Gyrus, anterior division	−0.03	0.07	−0.04	0.11	−0.16 ^¢	^Ξ 0.10	−0.16 ^¥	^⊙ 0.11	<0.0001	−0.04	0.08	−0.06	0.10	−0.09	0.11	−0.12 ^¥	0.10	0.0002
10		Superior Temporal Gyrus, posterior division	−0.04	0.08	−0.05	0.11	−0.16 ^¢	^Ξ 0.11	−0.16 ^¥	^⊙ 0.11	<0.0001	−0.04	0.08	−0.06	0.14	−0.08	0.10	−0.10	0.11	N.S.
11		Middle Temporal Gyrus, anterior division	−0.03	0.08	−0.06	0.13	−0.18 ^¢	^Ξ 0.13	−0.21 ^¥	^⊙ 0.15	<0.0001	−0.04	0.07	−0.07	0.14	−0.12 ^¢	0.12	−0.10 ^¥	0.10	<0.0001
12		Middle Temporal Gyrus, posterior division	−0.04	0.08	−0.06	0.12	−0.19 ^¢	^Ξ 0.15	−0.20 ^¥	^⊙ 0.12	<0.0001	−0.04	0.07	−0.06	0.12	−0.13 ^¢	0.12	−0.14 ^¥	^⊙ 0.11	<0.0001
13		Middle Temporal Gyrus, temporo occipital part	−0.04	0.06	−0.04	0.10	−0.16 ^¢	^Ξ 0.12	−0.16 ^¥	^⊙ 0.11	<0.0001	−0.05	0.07	−0.06	0.12	−0.12	0.13	−0.11 ^¥	0.10	0.0015
14		Inferior Temporal Gyrus, anterior division	−0.02	0.08	−0.07	0.13	−0.18 ^¢	0.13	−0.21 ^¥	^⊙ 0.20	<0.0001	−0.04	0.06	−0.08	0.12	−0.13 ^¢	0.12	−0.14 ^¥	0.11	<0.0001
15		Inferior Temporal Gyrus, posterior division	−0.03	0.09	−0.07	0.13	−0.18 ^¢	^Ξ 0.15	−0.19 ^¥	^⊙ 0.18	<0.0001	−0.05	0.07	−0.08	0.10	−0.12 ^¢	0.12	−0.14 ^¥	^⊙ 0.11	<0.0001
16		Inferior Temporal Gyrus, temporo occipital part	−0.02	0.09	−0.03	0.10	−0.15 ^¢	^Ξ 0.14	−0.16 ^¥	^⊙ 0.15	<0.0001	−0.05	0.08	−0.06	0.09	−0.11	0.12	−0.12 ^¥	0.09	<0.0001
34		Parahippocampal Gyrus, anterior division	−0.05	0.13	−0.12	0.15	−0.18	0.16	−0.27 ^¥	^⊙ 0.27	<0.0001	−0.04	0.06	−0.08	0.08	−0.11 ^¢	0.10	−0.14 ^¥	^⊙ 0.10	<0.0001
35		Parahippocampal Gyrus, posterior division	−0.03	0.16	−0.07	0.09	−0.11	0.14	−0.17 ^¥	^⊙ 0.21	0.0002	−0.02	0.05	−0.04	0.07	−0.08 ^¢	0.08	−0.07 ^¥	0.08	0.0001
37		Temporal Fusiform Cortex, anterior division	−0.02	0.15	−0.06	0.15	−0.15	0.12	−0.24 ^¥	^⊙ 0.30	<0.0001	−0.04	0.08	−0.07	0.09	−0.14 ^¢	0.09	−0.17 ^¥	^⊙ 0.13	<0.0001
38		Temporal Fusiform Cortex, posterior division	−0.01	0.17	−0.03	0.11	−0.14	0.12	−0.20 ^¥	^⊙ 0.26	<0.0001	−0.05	0.08	−0.07	0.12	−0.15 ^¢	0.11	−0.17 ^¥	0.12	<0.0001
45		Heschl’s Gyrus (includes H1 and H2)	−0.05	0.07	−0.06	0.11	−0.13 ^¢	0.10	−0.15 ^¥	^⊙ 0.12	<0.0001	−0.05	0.11	−0.06	0.16	−0.09	0.11	−0.08	0.12	N.S.
46		Temporal Planum	−0.05	0.08	−0.05	0.11	−0.14 ^¢	^Ξ 0.10	−0.15 ^¥	^⊙ 0.12	<0.0001	−0.05	0.09	−0.04	0.12	−0.08 ^¢	0.10	−0.08 ^¥	0.11	N.S.

Longitudinal average cortical thinning differences (mm), standard deviation (σ), and Tukey-Kramer multiple comparison post-hoc analysis in ANOVA (P). The data refer to: (d) CTR, (e) sMCI, (f) pMCI and (g) AD; α = 0.01 level.

¢: Significant difference between CTR and pMCI;

¥: Significant difference between CTR and AD.

Ξ: Significant difference between sMCI and pMCI;

¤: Significant difference between sMCI and AD N.S.: Not significant; CTR: Normal elderly controls; sMCI: stable MCI; pMCI: progressive MCI; AD: Alzheimer's disease.