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. 2015 Mar 10;10:1941–1952. doi: 10.2147/IJN.S78547

Figure 2.

Figure 2

Synthesis of DOX-loaded, PEI, fragment HAb18 F(ab′)2 and DMA decorated PMLA (DOX/HDPEPM) nanoconjugates.

Abbreviations: DMA, 2,3-dimethylmaleic anhydride; DOX, doxorubicin; EDC, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide; HDPEPM, nanoconjugate formed by covalent attachment of fragment HAb18 F(ab′)2 and 2,3-dimethylmaleic anhydride to polyethylenimine-modified poly(β-L-malic acid); Mal, maleimide; NHS, N-hydroxysuccinimide; PEG, polyethylene glycol; PEI, polyethylenimine; PMLA, poly(β-L-malic acid).