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. 2015 Mar 10;10:1941–1952. doi: 10.2147/IJN.S78547

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© 2015 Zhou et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Cellular uptake of different DOX-loaded nanoconjugates in Huh7 cells at (A) pH 7.4 and (B) pH 6.8 by flow cytometry.

Abbreviations: DOX, doxorubicin; HDPEPM, nanoconjugate formed by covalent attachment of fragment HAb18 F(ab′)₂ and 2,3-dimethylmaleic anhydride to polyethylenimine-modified poly(β-L-malic acid); PEPM, polyethylenimine-modified poly(β-L-malic acid); HPEPM, nanoconjugate formed by covalent attachment of fragment HAb18 F(ab′)₂ to polyethylenimine-modifid poly(β-L-malic acid); DPEPM, nanoconjugate formed by covalent attachment of 2,3-dimethylmaleic anhydride to polyethylenimine-modifid poly(β-L-malic acid); SPEPM, nanoconjugate formed by covalent attachment of succinic anhydride to polyethylenimine-modifid poly(β-L-malic acid).