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AmDM/DOX nanomicelles overcome drug resistance via macropinocytosis-mediated endocytosis and inhibition of drug efflux. (A) Inhibition of the uptake of AmDM/DOX micelles on MCF-7R cells using specific endocytosis inhibitors. CD: inhibitor of macropinocytosis; genistein: inhibitor of caveolae-mediated endocytosis; CMZ: inhibitor of clathrin-mediated endocytosis. (B) Inhibition of doxorubicin efflux by AmDM/DOX nanomicelles was determined in MCF-7R cells.
