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. 2015 Mar 18;9:75. doi: 10.3389/fncel.2015.00075

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Copyright © 2015 Hillje, Beckmann, Pavlou, Jaeger, Pacheco, Sauter, Schwamborn and Lewejohann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Flux distribution estimated by random sampling for the wild type and the mutant models built via the FASTCORMICS workflow. (A) Random sampling results. Ratio of the flux rates for phosphoglycerate kinase (PGK), phosphoglycerate mutase (PGM), and acetylphosphatase (ACYP) over glyceraldehyde dehydrogenase (GADP) represented in blue for the wild type and in red for the mutant. (B) Schematic representation of the qualitative wild type (dark gray) and mutant (light gray) fluxes over the glycolysis pathway.